our team

Yuval Shaked, PhD

Principal Investigator

Department of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion.

Former Head of the Rappaport Technion Integrated Cancer Center (RTICC).

 

Office: +972-73-3785215

Prof. Shaked’s lab pioneered the term “host response to anti-cancer drugs”— a patient’s response to cancer treatments, which may explain therapy resistance and cancer metastasis. He found that anti-cancer drugs, including chemotherapy, radiation, surgery, targeted drugs, and even immunotherapy, can contribute to cancer cell resistance or spread by provoking the body to protect its cancer cells from the toxic effects of treatments. This research has paved the way for new combinations of cancer treatments that block the body’s protective patterns, increase therapeutic outcome, and further support precision medicine in oncology. 

 Prof. Shaked founded the company OncoHost, a next-generation leader in precision oncology, which utilizes the host response effects to predict a patient’s outcome to therapy. Using data generated by OncoHost, Prof. Shaked published a study in November 2021 predicting lung patients’ response to immunotherapy. OncoHost, which won the Frost & Sullivan 2021 Technology Innovation Leadership Award, has raised at least $50 million and has a branch in North Carolina. 

Prof. Shaked also co-founded RemedyCell Ltd., a biotech company that takes the findings of the host response to anti-cancer treatments to other pathologies. The company is currently focusing on a novel therapeutic strategy for the devastating and incurable disease, pulmonary fibrosis. 

Prof. Shaked is a graduate of the Hebrew University of Jerusalem and earned his doctorate from the Department of Neurology at Hadassah University Hospital. He completed his postdoctoral training at the University of Toronto and joined the Technion in 2008 as a Landau Fellow in the Leaders in Science and Technology Program. 

A prolific author, Prof. Shaked has published more than 140 scientific papers. He holds more than 10 U.S. patents (in different stages of approval), and has received numerous scholarships, such as the prestigious European Research Council award and research grants including the Krill Prize for Excellence in Scientific Research. 

Ziv Raviv, PhD

Lab Manager

Abhilash Nitin Deo, PhD

Post Doctoral Fellow

Host response to immune checkpoint inhibitors and its implication on brain metastasis.

Madeleine Ben Guigui, MSc

PhD Student

The role of myeloid derived suppressor cells in immunotherapy – diagnostic and therapeutic aspects.

Rotem Menachem, MSc

PhD Student

Developing a targeted therapy for multiple myeloma.

Bar Manobla, MSc

PhD Student

ECM remodeling following immunotherapy – developing antibody-drug conjugate to improve immunotherapy outcome.

IMG-20221221-WA00001

Sapir Levin, MSc

PhD Student

The role of progenitors and mature hematopoietic cells in cancer immunotherapy – utilizing in-depth bioinformatics analyses.

Buxi01

Chen Buxbaum, MD

PhD Student

Deciphering the mechanisms underlying spontaneous regression of neuroblastoma (NB) - developing suitable murine NB models.

Shahaf

Shahaf Saad

PhD Student

Chen Sharon, BSc

MSc Student

Understanding how immune checkpoint inhibitors promotes metastasis through ECM remodeling induced by immune cells.

Elian01

Elian Far, MSc

PhD Student

Former Members

Sveta

Sveta Gingis-Velitski, PhD

liat

Liat Benayoun, PhD

Tali-Voloshin

Tali Voloshin-Sela, PhD

michal

Michal Munster, MSc

rotem

Rotem Bril, MSc

Valeria

Valeria Miller, MBA

Erez

Erez Hasnis, MD/PhD

Dror

Dror Alishekevitz , PhD

Chen R

Chen Rachman-Tzemah, MD, MSc

ofrat

Ofrat Beyar-Katz, MD/PhD

Orit

Orit Kaidar-Person, MD

ruslana1

Ruslana Kotsofruk, MSc

ksenia

Ksenia Magidey-Klein, PhD

dvir

Dvir Shechter MD, PhD

 

 

 

 

Avital

Avital Vorontsova, PhD

Timaner

Michael Timaner, PhD, MBA

Hila

Hila Berkovich, MSc

linkedin.com/Hila

Hila

 

lena

Yelena Ergas, MSc

Shimrit

Shimrit Avraham, PhD

Josephine

Jozafina Haj-Shomaly, PhD

Tim

Timothy J. Few-Cooper, PhD

Ella

Ella Fremder, PhD, MBA

Shiri

Shiri Davidi, MSc

tal

Tal Kan, PhD

Irena

Irena khononov Elias, PhD

Noga

Noga Barak, MSc

Dafna

Dafna Joseph, MBA

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